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ESR10 – Understanding and exploiting host-pathogen interactions in tick-borne encephalitis virus

Faculty of Biological and Environmental Sciences, University of Helsinki (Finland) 
This is a structural biology project that focuses on understanding how flavivirus envelope proteins recognise and bind host factors. We will apply state of the art cryo-electron microscopy and three-dimensional image reconstruction (3DEM) to the complexes as well as X-ray crystallography (e.g. Shakeel et al. 2017 (; Shakeel et al. 2016 The project will involve secondments to UK network partners for data collection (University of Leeds) and test laminin binding for preanalytical sample preparation for viruses at Elisha Systems Ltd.

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